Chromatin structure is dynamically regulated. I know that some genotoxic stress may cause chromatin relaxation. Does metabolic stress cause such as starvation and also cause similar structural changes in chromatin?
Genotoxic stress activates nuclear poly(ADP-ribose) (PAR) metabolism which results in PAR synthesis catalyzed by DNA damage accumulation has been reported to activate poly(ADP-ribose) polymerases (PARPs) and rapid PAR turnover by action of nuclear poly(ADP-ribose) glycohydrolase (PARG). PARP-1's functions are intimately related to nuclear NAD(+) metabolism and the broader metabolic profile depending on the cell context. That is why the functions of PARP-1 and PAR are affected by various extrinsic and intrinsic stress signals, including those initiated by oxidative, nitrosative, genotoxic, oncogenic, thermal, inflammatory, and metabolic stresses.
Yes, I think so. Recently, we have demonstrated the implication of mitochondrial oxidative stress induced epigenetic modifications. Starvation and other metabolic stress conditions greatly influences mitochondrial-nuclear cross talk, therefore, might insinuate changes in the epigenome too.
Article Mitochondrial Oxidative Stress-Induced Epigenetic Modificati...
Recently, We published a paper which might help you find answer to your question. We find changes in genome-wide nucleosomal positioning in response to salicylic acid treatment to Arabidopsis.
Hi,
maybe this overview can help you a bit:
https://www.researchgate.net/publication/7065888_Common_Pathway_of_Chromosome_Condensation_in_Mammalian_Cells
Article Common Pathway of Chromosome Condensation in Mammalian Cells
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