I have a patient (one year old girl) after IV phenytoin for controlling seizure she showed severe hyponatremia and after discontinuing that hyponatremia was controlled.
Did you have hyponatremia after IV phenytoin?
Dear Dr. Karimzadeh,
Thank you for your good question. Definitely the response is ''yes''
You can look at the following web address. in the background of a research study about 135 cases of phenytoin-induced hyponatremia have been reported between more than ten thousand people that were under treatment with phenytoin due to epilepsy,..
www.ehealthme.com/ds/phenytoin/hyponatraemia
I believe the answer is yes but the more difficult question is how. This can be partially due to the mechanism of action itself (being working partially on sodium channels). Phenytoin-Indices SIADH is another proposed mechanism as well. Interestingly with some paradox, phenytoin has been found to reverse hyponatremia induced by other sodium blocker AED, like carpamazipine.
Hi dear professor Karimzade. I had one SIADH case with phenytoin tx in Kerman that response to liquid limitation.thank you
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