Absolutely, firstly you will get broadening of metabolites as they will bind to proteins making quantification impossible and you will probably lose visibility of some of the lower concentration metabolites. Secondly there will be alterations in some clinical measurements and potentially chemical shifts.

See article by Denihan et al for an idea of the alterations in metabolites following haemolysis (d.o.i. 10.1016/j.clinbiochem.2015.02.004) 

Thank you for your answer !