Gene therapy is an insertion of functional gene in neighboring or instead of dysfunctional genes.
CRISPR /Cas9 has been implemented for editing human embryos
Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, et al. Correction of a pathogenic gene mutation in human embryos. Nature. 2017;548:413–9. 7
See also,
Fogarty NM, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, et al. Genome editing reveals a role for OCT4 in human embryogenesis. Nature. 2017;550:67–73.
Hello
Also the gene therapy was used for human Lung Adenocarcinoma
These links will help you :
Article Gene Therapy for Human Lung Adenocarcinoma Using a Suicide G...
https://www.ndsu.edu/pubweb/~mcclean/plsc431/students99/anderson.htm
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157865
Good Luck
Gene therapy has experimented in human beings long time ago. One person even died. See this 2001 paper.
Title: Death but one unintended consequence of gene-therapy trial Article Death but one unintended consequence of gene-therapy trial
From the paper:
"Jesse Gelsinger wanted to help others overcome the same metabolic disorder he had, so he agreed to enter a gene-therapy trial. A short time later, the 18-year-old American became the first person to die because of participation in gene-therapy research."
This is an interesting Timeline for gene-therapy (from New Scientists--https://www.newscientist.com/article/mg22029413-200-bubble-kid-success-puts-gene-therapy-back-on-track/)
Trials and tribulations of gene therapy:
- 1990 First approved gene therapy trial. Immune cells from 4-year-old Ashanti DeSilva are given working versions of the ADA gene to treat severe combined immunodeficiency disorder (SCID). It works, but only temporarily.
- 1992 ADA-SCID is successfully treated through gene therapy on stem cells harvested from bone marrow.
- 1999 18-year-old Jesse Gelsinger dies following an immune reaction to the virus vector used to insert the corrected gene. US Food and Drug Administration suspends several trials pending re-evaluation of ethical and procedural practices.
- 2000 Announcement that two boys in France with X-linked SCID or “bubble boy” disease have been cured using gene therapy.
- 2002 French SCID trial suspended after four children develop leukaemia as a result of the retrovirus vector.
- 2003 Chinese company Shenzhen SiBiono GeneTech gains approval for treating head and neck cancer with Gendicine, a modified adenovirus carrying a tumour-suppressor gene.
- 2003 Researchers in the US begin the first human trial using a modified lentivirus. It is a disabled HIV virus carrying a gene to inhibit replication. Trial is a success.
- 2009 Eight-year-old Corey Haas, who has a rare inherited eye disease and is almost blind, gains normal vision following gene therapy to replace a retinal pigment protein.
- 2009 Progression of the degenerative disease adrenoleukodystrophy is halted in two boys using gene therapy.
- 2010 An adult with blood disorder beta-thalassaemia no longer needs monthly blood transfusions following gene therapy to insert a corrected beta-globin gene into stem cells that make blood.
- 2011 Six people with clotting disorder haemophilia B see a reduction in symptoms after gene therapy on liver cells.
- 2012 Glybera becomes the first gene therapy drug to be approved in the West, with European approval to treat lipoprotein lipase deficiency.
- 2013 Two papers describe the treatment of children with a degenerative disorder called metachromatic leukodystrophy and immune disorder Wiskott-Aldrich syndrome using gene therapy (Science, doi.org/pnv; doi.org/ppk).
Also see this story (2013 Nov.):
Title: ‘Bubble kid’ success puts gene therapy back on track--Five children with a genetic disease that wipes out their immune system have successfully been treated with gene therapy.
Those children were born with no immune system. After gene therapy (replace a faulty gene with a normal copy), now their white blood cells almost doubled (meaning they have an immune system now).
https://www.newscientist.com/article/mg22029413-200-bubble-kid-success-puts-gene-therapy-back-on-track/ (cope and paste to veiw)
ClinicalTrials.gov is a very useful database proveding information about gene therapy clinical trials in different countries around the world.
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