Methylfolate has been shown to help SSRIs work better in patient with difficulty converting folate to methylfolate. Deplin is methylfolate and it is being widely used to augment SSRIs in partial responders. Other supplements have combinations of methylfolate with other ingredients including follinic acid.
Article Folinic Acid (Leucovorin) as an Adjunctive Treatment for SSR...
It might, but how it gets into the CNS, what is its dose, and if it is orally available versus intravenous are the questions to be addressed. It indeed bypasses the enzyme MTHFR just like methylfolate, but may not be as practical way to do it.
Given that folic acid is cheap and likely innocuous, it may be worth a trial figuring out whether is helps. The mentioned study may be point to depart from, but I advise to be careful: (1) it is a small, unblinded trial, (2) in neurology, there was a lot of homocysteine, MTHFR, and folic acid substitution addressed in huge trial called VITATOPS, which failed to demonstrate any effect of supplementation despite some studies and pathophysiological ideas supporting supplementation. Maybe a placebo effect as well, which would seem ok to me if it helps...
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