I want to study the evolutionary impact of two proteins on each other from a single species, can it is possible to study through phylogenetic or computational methods and what tests and parameters I should consider during analysis.
Hi Sandeep, the closest thing I could think of is sickle cell hemoglobin (single point mutation that is thought to protect carriers from malaria) and its effects on actin.
https://www.nature.com/news/sickle-cell-mystery-solved-1.9342
There are a lot of works on co-evolution of proteins. You may look into the works of Prof. Sudip Kundu of University of Calcutta. Such as these:
https://academic.oup.com/nar/article/43/11/5352/1174111
https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.25292
Article Co-evolutionary constraints of globular proteins correlate w...
https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.24960
http://www.academicjournals.org/journal/JCBBR/article-abstract/FF035ED9875
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