The most basic explanation of Multiple Sclerosis symptoms states that demyelination impairs the neurons ability to conduct messages, akin to an electrical cord losing insulation.
When the protective layer of myelin sheath is lost, would that also expose the neurons to a greater saturation of brain chemicals?
The attached article states that while serotonin in the brain helps drive our ability to exercise, when it reaches excessive levels on the axon initial segment, the overload causes the muscles to fatigue and shut down.
Multiple Sclerosis patients not only suffer weakened muscles, they often suffer a central, systemic fatigue - the etiology of which is still unknown. Could the loss of myelin sheath rapidly expose the neurons to excessive levels of serotonin, causing them to fatigue with minimal exertion - irrespective of the neurons ability to transmit messages?
http://www.sciencedaily.com/releases/2013/03/130304151805.htm
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