Dear Jinan,
Just recently this year, Dr. Ostrakhovitch et al. demonstrated that a subset of cancer cells, upon recovery from a potentially lethal damage, undergo dedifferentiation IN VITRO and express genes, which are characteristic of undifferentiated stem cells (Experimental Cell Research, vol. 330, issue 1, 2015, pp. 135–150 entitled “Dedifferentiation of cancer cells following…” ). While these cells are competent in maintaining differentiated progeny of tumor, they also exhibit trans-differentiation potential.
Best wishes,
Ilya
Thanks Dear Ilya for your suggestion, but can we really state that the cells that escaped strong chemical damage were dedifferentiated and acquired sphere formation capacity and expressed stem cells markers. Is not possible that an endogenous small population with stem cell properties exists in this line, and that this population was resistant to the induced damage and took over the culture that lost most of other cells by the chemical damage. In other words, is not this type of stress just an enrichment for resistant stem cell population more than dedifferentiation?
An elegant study from Luis Parada's lab shows that it is unlikely that the origin of glioma is from mature neural lineage that could go under dedifferentiation and malignant transformation https://www.nature.com/articles/s41593-018-0333-8
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