Does Coffee (Caffeine) Reduce the Risk of Premature Death in a Human with Kidney Disease? Early study (which needs to be replicated) suggests that coffee (caffeine) may lengthen life in a human with kidney disease.
--Patient consuming least amount of caffeine saw no reduction in premature death risk.
--Patients with most caffeine consumed reduced risk of premature death by 24%
Questions:
1. Is there anything in this study that can be communicated to patients from this study? If so, what?
2. Should all hold of telling the patient with chronic kidney disease anything until a new replication study is undertaken?
Dennis
Dennis Mazur
1) The SUN ( Seguimiento Universidad de Navarra) project included 19,896 participants that showed an inverse association between drinking coffee and the risk of all-cause mortality, particularly in people aged 45 years and above. This may be due to a stronger protective association among older participants
2) A new study showed that among more than 2,300 Americans with chronic kidney disease, those who drank the most caffeinated drinks reduced their risk of premature death by 24 percent. Lead researcher Dr. Miguel Bigotte Vieira, from the Centro Hospitalar Lisboa Norte, in Lisbon, Portugal, said, "Our study showed a dose-dependent protective effect of caffeine consumption on all-cause mortality among patients with chronic kidney disease. However, our observational study cannot prove that caffeine reduces the risk of death, but only suggests the possibility of a protective effect.Moreover, the reasons that caffeine might be protective aren't clear, and how much caffeine is too little and how much might be too much also isn't known"
3) In the latest study, published in the journal Annals of Internal Medicine, researchers have carried out the largest analysis of the effects of coffee-drinking in a European population - where coffee consumption and preparation methods vary, from an espresso in Italy, to a cappuccino in the UK - finding a similar association between consumption and mortality. [Coffee drinking and mortality in 10 European countries' by Gunter, M.J. et al, is published in the journal Annals of Internal Medicine. 07/10/2017 DOI: 10.7326/M16-2945]
Summary. There are small studies of coffee being harmful, beneficial and having no effect on health; so I think: a) we do not need to talk CKD patients that the more caffeine they drink, the longer they'll live; b) more scrupulous multinational observation and evidence-based research is needed
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