Does chlamydia infection trigger any upregulation in glycolysis gene expression in the host cell?

10 October 2017 1 5K Report

I know chlamydia uses some glycolysis enzymes ,that they lack, from the host cell, does that uptake of enzymes trigger any homeostatic event from which the host cell would upregulate some genes expression levels ?

Harrie A Verhoeven

Dear Angelo,

The Chlamydia story keeps popping up, but it has been shown a long time ago that at least some Chlamydia species can provide their own energy through glycolysis: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.1999.01464.x/full. 3-BP may be a useful inhibitor for the glycolysis of Chlamydia since it inactivates several enzymes of the glycolytic pathway irreversibly. Kind regards, Harrie Verhoeven.

Badges
Science topic

More Angelo Demeter's questions See All

How much time is lipid:siRNA complex stable ?

08 September 2017 4,498 6 View

How do you make TiO2 solution from TiO2 powder?

I want to test the food colorant E171(titanium dioxide) on some human lung fibroblast for my bachelors thesis. I have bought some TiO2 99+% powder but I wish to know how to make the solution and...

01 February 2015 4,315 10 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Genome-wide gene identification protocol ?

Is there any book chapter/book, webpage or research article available to understand genome-wide gene identification?

28 February 2021 8,095 1 View

Any specific pipeline or parameter to analyse total transcriptomics study of brain tissue samples?

I have two groups of brain samples, control and treated for example. It was total RNA nova seq sequencing. I tried all the available pipeline like: star+rsem+deseq2, Hista+stringtie+cuffdiff,...

27 February 2021 356 6 View

RNA-seq DEGs downstream analysis and reporting in literature?

I used EdgeR to get the list of DEGs (differentially expressed genes) from my liver RNA-seq experiment. I have done the gene overrepresentation and GSEA based pathway analysis. I am currently...

23 February 2021 8,969 1 View

Could you please suggests a tutorial or paper or any other materials to learn multiple gene expression in TCGA and GTEx databases?

I would like to analyze multiple gene expressions in normal and cancer tissue by using the data in the TCGA and GTEx databases. Please suggest a tutorial or paper showing step by step analysis of...

23 February 2021 9,007 3 View

Are there any databases for gene co-expression or expression pattern clustering?

I am currently working on gene clustering based on co-expression pattern in mouse brain. The problem is I do not have some solid way to test my result. Are there any suggestions for databases...

22 February 2021 4,374 3 View

Which CpGs have a significant effect on gene expression?

It is known that methylated CpG around TSS decreases gene expression. However, It is difficult to know exactly which CpG has a greater impact on gene expression. Are there any databases known...

20 February 2021 5,634 3 View

I can detect my protein but the encoding DNA sequence has stop codons within. Should I ignore the stop codons?

I constructed a synthetic DNA library (scFv, VH-VL orientation) with a 3' reporter and 8x histag. I cloned and expressed this gene following which I performed an ELISA. The ELISA results suggested...

19 February 2021 7,006 5 View

Purification of proteins from baculovirus-infected insect cells?

18 February 2021 6,665 6 View

Found that there was a multiple band when amplifiying targeted gene ?

i few days ago amplified specific gene using PCR with specific primers, but there was a multiple band in electrophoregram i found. out of 10 sample amplified, there was multiple band and there was...

18 February 2021 5,131 5 View