27 November 2022 1 10K Report

A transcription factor, by definition, is a: molecule that controls the activity of a gene by determining whether the gene’s DNA (deoxyribonucleic acid) is transcribed into RNA (ribonucleic acid).

source: https://www.britannica.com/science/transcription-factor

So to go by definition, β-catenin should count as one, since it (through TCF/LEF) controls the expression of Wnt target genes. However, I've rarely ever see it mentioned as such. Most studies I've come across call it a coactivator of transcription factors, so I'm not sure whether my terminology is acceptable. I mean, can I call it a transcription factor in my thesis/publication?

(P.S. here are 2 examples I found where they do deem it as one:

  • β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1
  • Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids
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