Dear all, I'm conducting the revisions of some of my manuscript, with is the impact of the combination of Aspirin and a fruit juice in colorectal cancer cells. Two of the reviewers have asked to calculate the substance interaction index, but the juice is not a pure substance, but a mixture of thousands of components (we only quantified some polyphenols). Does it make sense to calculate an interaction index? Thanks in advance for your help.
Check https://www.tandfonline.com/doi/abs/10.1080/10543400701199593
Also check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796809/
Hi,
Reviewers seemed to have asked a general question, but you need to experimentally observe more clearly into the physicochemical/interfacial phenomena of the object of your study. For instance, aspirin is a poorly water-soluble drug with a pKa of 3.5. Generally, polyphenol molecules have both hydrophobic moieties and hydrophilic hydroxyl groups. The interaction between polyphenols and aspirin probably greatly depends on your assayed conditions, which would ultimately influence your evaluated index (ex vivo).
Good luck.
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