Herbut et al. reported that 'congenital absence' of the muscular layer of stomach is a predisposing factor in spontaneous gastric ruptures. [3] However, Shaw et al. experimentally concluded that this histological appearance is likely to be a result of retraction of the muscular layer from the perforation site. [4]
Attached is the publication from which I extract these sentences.
http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2010;volume=7;issue=1;spage=33;epage=35;aulast=Akcora#ft3
That's interesting. I assumed that this was a mouse/rat/rodent with glandular and non-glandular/squamous portions of the stomach - in which case, the muscular wall is pretty thin to begin with and what we're seeing may be the folds and corrugations formed by hyperplastic gastric epithelium as seen through the thin muscular wall. Is there any more information that you can give us about this, Tom?
These conditional knockouts develop this with age. This mice is 40 wks.
I didn't had a look yet to sections of this.
Maybe you can contact me to discuss this in more detail though email:
hyperplastic polipoid lesion….. diverticulosis…. defect in muscular wall.
With a simple biopsy and histological examination you will resolve the differential diagnosis….
Not much information to go on. Presumably this is a view from outside the stomach since there are bowel loops in the background? Is this human, mouce, newborn? What's the cause of death? More information neeed. Sorry
Biopsy and histological examination probably resolve the diagnosis.
Is this human stomach? Quite difficult to assess based on this single photograph. Perhaps other perspective views and view of the OPENED SPECIMEN detailing the gross appearance may be helpful. Of course, histopathological correlation would be in best order. Its uncertain to say if this indeed depicts the absence of the muscularis layer? Please provide us with a follow-up of this interesting pathology. Thank you.
I tend to agree with the opinion of Dr Virginia Gillespie on the possibility of a hyperplastic gastropathy (perhaps the equivalent of Ménétrier’s disease?). The ridges along the stomach wall (rugae) seems to be quite enlarged, forming giant folds in the stomach lining. In this pathology, the rugae enlarges because of an overgrowth of mucous cells in the stomach wall, hence histopathology correlation may resolve the diagnosis.
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