i am planning to do a research about vanadyl sulfate as an antidiabetic agent on a mice i will learn to study in correlation with the apoptotic and proliferation in pancreatic beta cell. does anyone have an information about the newest information of vanadyl sulfate? thank you in advanced
Dear Ms Nisak,
The transition metal, vanadium, is well known to form coordination complexes with many proteins and other biological constituents, membranes and other cellular components. The average body load of vanadium in humans amounts to 1 mg. A number of studies have been performed on inorganic and organic vanadium derivatives in animal models of induced diabetes. Several studies have also elucidated the therapeutic effect of vanadium compounds on plasma glucose levels in individuals with diabetes. Vanadyl sulfate has received attention as a therapeutic agent in the treatment of type 1 diabetes, in view of its insulin-like function (by replicating insulin actions mediated by insulin receptor tyrosine kinase activation and kinase phosphorylation cascade pathways). Vanadyl sulfate treatment has recently been reported to stimulate the proliferation and regeneration of beta cells in pancreatic islets of STZ-induced diabetic rats.
Regards...
Vanadium (oxidation state IV) in the form of vanadyl sulfate has been assessed for its efficacy in individuals with 2 diabetes, and the results showed that vanadium dose-dependently accumulated in the serum. However, in the initial study no relationship between total serum vanadium concentration and insulin-like response was observed in attempting to correlate antidiabetic activity with total serum vanadium. could be made Although V accumulation in serum was dose-dependent, no correlation between total serum vanadium concentration and insulin-like response was found in this first attempt to correlate anti-diabetic activity with total serum vanadium, suggesting that vanadium pools other than total serum vanadium are likely related to the insulin-like action of vanadium.
You can get benefits from this article; Fedorova EV, Buryakina AV, Zakharov AV, Filimonov DA, Lagunin AA, Poroikov VV (2014) Design, Synthesis and Pharmacological Evaluation of Novel Vanadium-Containing Complexes as Antidiabetic Agents. PLoS ONE 9(7): e100386. doi:10.1371/journal.pone.0100386
Thank you so much for tha answer dear Chithan C Kandaswami and Mohammed H F Shalayel
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