I am looking for a protein whose expression level does not change during the growth of S. aureus.
Hi. Which time point of growth? Do you mean during the exponential phase?
And what do you mean by "remains the same"? Usually protein level are changing, but the majority of them will not be deferentially expressed, is that what you mean?
I suggest you to search on proteomics study on S. aureus, and you will find people analyzing their proteome change under different conditions (e.g. our group has previously published an article analyzing the proteome changes of S. aureus under oxacillin antibiotic treatment. Here's the link:
Article Label-Free Quantitative Proteomics Analysis of Antibiotic Re...
We saw only a few up-regulated and down-regulated proteins, and most of the proteins level are not deferentially expressed).
From these studies, you can find both the not deferentially expressed proteins and the deferentially expressed (down & up-regulated) proteins.
It depends wether the protein/ may be an enzyme is expressed constitutively or is inducible. In former it may remains may or less same.
There are a number of proteins whose expression remain relatively invariant across growth conditions. Although I do not have data on S. aureus, I have looked at some other microbes and a good candidate is DNA polymerase (polA).
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