Does anyone know a bioactive molecule or bitter edible compound that can not bind to whey proteins ?

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Sascha Rohn

You can try the relatives of caffeine: Theobromin, theophyllin. Bitter compounds with a phenolic ring such as naringenin will bind heavily to whey proteins...

Iman Katouzian

Many thanks Prof. Rohn.

Do you have any idea of how oleuropein (bitter compound of olive leaf extract) interact with whey proteins?

We never tested its interaction before, but from its many carbonyls, hydroxyls, aromatic rings and double bonds, it seems to me as pre-requiste compound for binding it to proteins...