Hello, is anyone aware of examples of kinase inhibitors active against mutated forms of the target that show a higher potency against the mutated form of the kinase than against the wt? If so could you please send me the reference?
Thank you
There are many examples. One of the first examples I am aware of is this one:
http://www.nature.com/nature/journal/v462/n7276/full/nature08622.html
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