Fabio Zuccotto

5 Questions 18 Answers 0 Followers

Questions related from Fabio Zuccotto

In silico Druggability?

Hello, would like to explore "reliable" in silico approaches to Target Druggability, any suggestion? Thank you.

20 March 2016 5,392 5 View

In-silico approaches to define/design drug–target residence time?

Hello, what would be the best in-silico approach to rationalise/design drug-target residence time? Thanks

02 March 2016 6,153 2 View

Is there any software to calculate the permeability coefficient of small molecules?

I am interested in tools that will allow in silico prediction of permeability coefficient

20 May 2015 6,207 4 View

Does anyone have experience with Kinase inhibitors active against clinically relevant mutated form?

Hello, is anyone aware of examples of kinase inhibitors active against mutated forms of the target that show a higher potency against the mutated form of the kinase than against the wt? If so...

11 August 2014 8,188 1 View

Is there any database containing info related to the several kinase mutants generated by the clinical use of kinase inhibitors?

06 April 2014 5,365 2 View