Familial or hereditary essential tremor appears to follow an autosomal dominant mode of inheritance. Genes for familial essential tremor have been identified and linked to chromosomes 3q and 2p and 6p and some potential related genes.[See attachements and link] However, these gene mutations are rare and a common essential tremor genotype responsible for most familial essential tremor has yet to be identified.Several explanations have been put forth to explain this challenge, including the possibility of mutations in non-coding areas of the genome.
Any suggestion or research experiences about this domain?
Thanks All
http://www.ncbi.nlm.nih.gov/pubmed/9288103
All you have to do your research experience. Good luck.
http://www.mayoclinic.org/diseases-conditions/essential-tremor/basics/causes/con-20034509
http://en.wikipedia.org/wiki/Essential_tremor
http://ghr.nlm.nih.gov/condition/essential-tremor
I would suggest the article by Kuhlenbaumer et al, in Neurology 2014 for a starting point.
I agree with these authors that there are a lot of reasons why research in ET genetics is extremely difficult. It would probably be a good idea to start a multicentric study with very stringent inclusion criteria in order to avoid a large number of phenocopies. Alcohol responsivity e.g. could be a necessary inclusion criterion.
Thanks "Doc",
I had lost this paper... downloaded from his eminent colleague just now.
I have attached the file to clarify to any other investigators.... more or less experts
Sharing link,
https://www.google.es/url?sa=t&source=web&rct=j&url=https://www.researchgate.net/profile/Davide_F_Castaldi/post/Does_anyone_have_any_suggestions_about_Familial_Essential_Tremor_FET_genotyping_or_Phenotyping/attachment/59d6219c6cda7b8083a1b083/AS:273772370694144%401442283827761/download/FET%2BGenotyping%2Bor%2BPhenotyping_2014.pdf&ved=2ahUKEwiW7-jG2t_ZAhXIuRQKHcR5C-cQFjADegQIBRAB&usg=AOvVaw3mxTP5E4J1RRmZqmk-Ebs-
Regards!
- Badges
- Science topic
- Similar topics
- Biological Science
- Neuroscience