Dear Sandra, I have used an antibody to the clone APP 22C11 before on post-mortem tissue of patients who had traumatic deaths and saw lots of diffuse axonal swellings in the white matter. More recently, we showed in a rat model of needlestick injury and saw lots of intraneuronal APP upregulation in neocortex and hippocampus as well as in the axons of the WM. 

Also, there are several other clones available in the market for APP, but I think it's a good way to start. I used this MAB348 from Merck Millipore.

See: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059740

Dear Sivaraman

Thank you very much for your input.  Your suggestions really help me now that i just started to work on APP.  I appreciate your contribution.  I will keep you posted!

thanks again

sandra

Glad it helped :)

Good luck with your work.