Does anyone have a protocol to orally induce diabetes type 2 in mice?

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Vladislav V Kiselyov

A high fat diet is a common way of inducing a diabetes type 2 like condition in mice. See this topic for more information:

https://www.researchgate.net/post/What_doses_of_high_fat_diets_are_used_to_induce_type_2_diabetes_in_rats_or_mice

Ayman F. Refaie

I advise you to have a look for these excellent Papers:

1- Animal models in type 2 diabetes research: An overview. BY: K. Srinivasan & P. Ramarao

2- Treatment of high fat diet induced type 2 diabetes in C57BL/6J mice by two medicinal plants used in traditional treatment of diabetes in the east of Algeria.

3- A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice

Ashok Tiwari

It may also be induced by feeding sucrose and fructose solutions. Refer to :Pharmacologia 4 (3):197-207,2013