I am working with antimetastatic compounds and would like to compare their activity with some other compounds. Maybe somebody know any approved drug from cancer metastasis? Or maybe somebody know good positive controls for migration and invasion assays in vitro or for both of them?
Dear Vilma Petrikaite!
Here is my answer. Pleasecheck it and come back to me!
Sincerely Yours!
Dr. Bratko Filipič
Email: [email protected]
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Abstract
In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ‘migrastatics’ for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.
Keywords: solid cancer, metastasis, invasion, treatment, contractility, migrastatics
Here is the Article! Please check it!
Sincerely yours!
Dr. Bratko Filipič
Email: [email protected]
May be this manuscript may help you in your search
Working Paper METASTASIS PREVENTION WITH REPURPOSED DRUGS
Best regards
Article Voltage-gated sodium channel as a target for metastatic risk...
The above mentioned article may also be of some help
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