Differences that may cause a pathologist to identify cancerous cells vs. nomral cells.Is identification depend on the types of the cell that is evolved or not?
Well, for the Preliminary identification between a cancerous cell and a Normal cell, you have to observe the shape and size of the cell, area of the cytoplasm and its nucleus. You can also compare the specialized cell feature of the tissue. As Cancer cells can grow to invade. Normal cells stay where they belong within a tissue; The ability of cancer cells to invade reflects the fact that their growth and movement is not coordinated with their neighboring cells. This ability to invade is how cancer spreads to and damages nearby tissues.
There is one research article entitled as “Cytological Differences between Normal and Malignant Human Cell Populations in Culture”, it might help you to understand the physiological characteristics of a cancer cell in a better way!
Kind regards
Debasish
Interpretation of cytology is based on the complex of features, including cellularity, architecture, nuclear features, nucleo-cytoplasmic reatio, presence of mitosis and/or necrosis etc. You are right that identifiation of malignancy in some cases is based on specific features, typical for some cancers. In addition, you can use motelular testing when having indeterminate cytology
Of course,I mean cells affected in glioblastoma and differences in their cytoskeletal characteristics versus normal glials.
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