Recently i started work on MRI Contrast agents, in my experiment i found Mn2+ doped nano particles showing its good for T2 but in literature i found Mn2+ better for T1, Could you please anyone can explain or what is the disposable reason??
There are several good reviews about nanoparticles, used in MRI, for example
1. Hyon Bin Na, In Chan Song, and Taeghwan Hyeon, Inorganic Nanoparticles for MRI Contrast Agents, Adv. Mater. 2009, 21, 2133–2148
2. Petr Hermann, Jan Kotek, Vojtěch Kubíčeka and Ivan Lukeš, Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes, Dalton Trans., 2008, 3027-3047
Mn2+ and Gd3+ are used in T1 contrast agents because of large amount of unpaired electrons (5 and 7 correspondingly) in symmetrical state. So momenta is large, this shorten T1. In these reviews you can find more information about that.