Lipase enzyme is one of the digestive enzymes responsible for the digestion of fats, which facilitates the process of breaking down fats and facilitates its digestion by regulating chemical reactions in the body and reducing energy consumption. It is also responsible for the transmission of cholesterol in the body, so what is its effect on triglycerides?
Lipases are enzymes that play a crucial role in lipid transport. There are many different types of lipases. Hepatic lipase in the liver is responsible for degrading the triglycerides that remain in intermediate-density lipoprotein (IDL). Hormone-sensitive lipase is found within fat tissue and is responsible for degrading the triglycerides that are stored within adipocytes. Lipoprotein lipase is responsible for degrading triglycerides that circulating from chylomicrons and VLDLs. Pancreatic lipase is found within the small intestine and is responsible for degrading dietary triglycerides. Hepatic lipases play a role in the conversion of very-low-density lipoprotein into intermediate-density lipoprotein (IDL) and LDL by its triglyceride lipase activity. This enzyme also has the function of the remodeling of large, triglyceride-rich HDLs into smaller ones. HTGL is reported to enhance the hepatic uptake of HDL lipid. Human HL deficiency is characterized by increased IDL-cholesterol levels as well as large and TG-rich HDL particles. Some patients with HL deficiency were reported to have premature atherosclerosis.
https://www.ncbi.nlm.nih.gov/books/NBK537346/
https://www.sciencedirect.com/topics/medicine-and-dentistry/triacylglycerol-lipase
Intersting topic but it is out of my scientific fields. I follow the question.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/triglyceride-lipase
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/triglycerides
Lipases hydrolyze triglycerides (fats) into their component fatty acid and glycerol molecules. ... Lipases in the cells of adipose tissues break down the triglycerides so that fatty acids can reenter the bloodstream for transport to energy-requiring tissues.
VLDL is secreted from the liver and is metabolized by lipoprotein lipase, a capillary-bound enzyme that removes the triglyceride from the particle.
High triglycerides may contribute to hardening of the arteries or thickening of the artery walls (arteriosclerosis) — which increases the risk of stroke, heart attack and heart disease. Extremely high triglycerides can also cause acute inflammation of the pancreas (pancreatitis).
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