I am new to in vivo research. I have tried to induce solid tumors in mice by injecting 4T-1 cells in the mammary fat pad, which is an established procedure. While i mostly ot solid tumors, 2 or 3 of them developed ascites-type tumors with swollen bellies. This may have been due to an accidental intra-peritonial injection. Has anybody noticed this phenomenon before? Also, can anybody please direct me towards any published research along these lines? It will help me a lot. Thanks in advance!
I had similar observations many years ago in C3H mice. There, our pathologists told me that the ascites was a consequence of injection-associated lipoma. We then moved to tumour induction subcutaneously in the legs of the mice.
W.
Thanks, Wolfgang. But my question is, can i consider this type of ascites as a cancer model?
Hello Adhiraj Dasgupta,
what mouse strain do you use for your experiments?