No, RNaseZap or RNase away spray is not enough for Benchtop, plasticware and glassware decontamination when working with RNA.
You should be extra careful when you work with RNA. The presence of RNases on human skin surfaces can cause RNase contamination if tubes, pipette tips, bench tops, etc. are touched with bare hands. The dust particles floating in the air often harbor bacteria or mold which carry RNases that are deposited wherever the dust settles which includes lab equipment, open bottles, etc. Even the reagents used for RNA analysis if not certified to be RNase free, can cause some RNase contamination. Sometimes, reagents can also become contaminated in the lab itself if proper care is not taken. Also, RNase contamination can come from the samples themselves as tissues and cells contain endogenous RNases.
So, to prevent RNase contamination, in addition to RNaseZap or RNase away spray, one need to wear sterile disposable gloves when handling reagents and RNA samples. Change gloves frequently as you proceed with the steps towards getting more purified material. Use disposable plasticware which greatly reduces the possibility of contaminating your samples, and they are usually RNase-free which you need to check with the supplier. Using disposable tips, tubes, etc. is therefore highly recommended for RNA work. If you are using non-disposable plasticware you should treat them before use to ensure that they are RNase-free. Plasticware should be soaked in water containing 0.1 N NaOH and 0.1% EDTA overnight followed by thorough rinse with RNase-free water. Always use
DEPC-treated water for RNA work. If DEPC-treated water is made in-house, always remember to autoclave before use to degrade the DEPC. The use of RNase inhibitors is highly recommended because it greatly helps for samples containing endogenous RNase.
Extra precautions need to be taken while working with RNA.
I actually just spray everything well with ethanol and then I am super careful when handling my samples. Use RNAse free tubes for reagents to be used during RNA extraction, and RNAse free pipette tips (it is worth the extra expense). I spray everything with ethanol even my pippettes and tip box etc. (but you could use RNAse away). Wear a lab coat during extraction and use gloves (constantly spraying between steps with ethanol). Are you experiencing contamination problems? I found that if this is the case it is usually from the extraction part, I use basic trizol/chloroform method.
So in my experience, there is several approaches to RNA work, that work well. Having a clean and maybe dedicated area for the RNA extraction is a big help but not a necessity.
When I clean, I mostly use the RNA Zap to thoroughly clean, all surfaces, tip boxes, lamps and surfaces that might be above my tubes(close vicinity not on the ceiling :), like benchtop lamps and boards to store buffers on etc. directly above), pipettes as well as my gloves right before I start. Wear a lab coat to avoid RNases from your skin contaminating you samples. Apart form that there is other methods as well. RNases should be denatured by by ethanol, however I always heard that to achieve that you need to soak for example your glassware for an hour or longer to really get rid of everything.
Other methods include baking your glassware at 180°C for a couple hours or using hydrogen peroxide (3%) to soak your plastic ware for 15 mins.
There is also RNase inhibitors available eg. from NEB.
Overall what always worked for me was having an area with nicely cleaned surfaces. Clean pipettes and just grabbing a unopened still wrapped pack of tips which from then on are stored in a cleaned drawer for RNase free stuff. And RNase free water for all buffers and re-suspensions. All of that can be done with RNA Zap. And if you know you will store your samples for a time you can snap freeze them directly before storing at -80°C to slow down any potential degradation.
See which precautions work for you in your lab, and check if you get degradation, if not you should be good to go. Everyone handles it slightly different and its easy to become a bit overly cautious with it.
You should consider many approaches useful that may keep away the contamination. Following such as DEPC treatments to all, use of RNase ZAP too, extra precautions during extraction, use of single work bench or area, use of Laminars etc.