In our proposed hypothesis (2005), the leading role in the development attacks of breathlessness in patients with bronchial asthma given to hyperactivity of the bronchi. The specific immune response in the bronchi walls, realized for the destruction of tissue forms fungi of the genus Paecilomyces and limit their proliferation in lung tissue.Eosinophils play an important role of effector cells in the antibody-cell - mediated cytotoxicity (see appendix).
In my opinion eosinophil is a barrier breaker (independently to the fact if the effect is addressed to infectious/parasitic organism or to mucosal barrier like the bronchial one). Therefore, it develops hyperreactivity due to epithelial damage/denudation and local nerve irritation. In addition, the survival effect due to nerve growth factor (NGF) is insufficient because of low expression of respective receptors tyrosine kinase A (TrkA) in epithelial cells in bronchi. You can see the address: the www.novapublishers.com/catalog/product_info.php?products_id=31360&osCsid=dd67b6261b0c086c85e8f2108701869f
(Mingomataj et al. The magic eosinophil: a breaker of biological barriers. In: Eosinophils: Structure, Biological Properties and Role in Disease. Ed: Walsh GM. Novapublishers Inc. 2012, ISBN: 978-1-61122-270-8).
sorry, I don t have any information about this, but I check ed the site that intruduction ervin is use full,
Dear Ervin! In my report, I outlined and illustrated the well-known organism readjustment mechanism of non-phagocytosis-size microorganisms, when specific antibodies bind antigen on a surface of the target cells - and through the Fc-fragment are attracted to its destruction of certain implementing cells (NK and eosinophils).
Eosinophils have receptors for IgE and IgA, NK - for IgG.
In 1989-1991 years of the last century (Akhunova AM and Shustov VI) in the sera of patients with asthma have been identified specific IgE- and IgG-allergen antibodys to fungus of Paecilomyces.
T lymphocyte dependent and mediated by IL-5, immune inflammation involving eosinophil typical for allergic diseases.
I showed the initiation of inflammation by tissue cells of fungi of the genus Paecilomyces, using cytology of bronchial secretions from patients with asthma. The same immune defense mechanism has been found in blood, tissues of bronchial tissues and other organs. Moreover, in inflammation take part lymphocytes and monocytes (see annex).
- Badges
- Science topic
- Similar topics
- Methodology
- Laboratory
- Cellular Biology Techniques