I am interested in exploring the contribution of obesity in murine wound healing without the characteristic hyperglycemia of diabetic mice.
I have considered the use of an obese diabetic mouse raised on high fat diet, and then later attempting to suppress the hyperglycemia, but I fear that the mouse *ever* having high blood glucose levels may affect the long-term function of the immune and regenerative cells.
I am looking into Non-obese diabetic (NOD) mice, but an obese non-diabetic would be great.
Thank you for your time. Any advice would be welcome.
-Jordan
Hi, if you challenge your animal with hfd they will become obese before becoming diabetic so you could use them during this time frame. You could also feed them during light cycle only, where studies show that even with CD they gain more weight.
Hi, Jordan,
According to the answer of Marie, You can also submit preferencially rats To fructose diet (65%) or high fat diet or cafeteria diet in order to induce obesity and insulin resistance. That's the good model for the study of insulin resistance !!!!
Regards !
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