Do you have observational evidence indicating that Zika virus infection could enhance the pathogenesis of subsequent dengue virus infection?

12 July 2017 1 10K Report

Following the Zika virus epidemic in the Americas, a large proportion of the population has likely been immunized to Zika virus. Kawiecki et al reported DENV-2 enhancement by Zika virus-induced antibody response in vitro. Are there arguments that can make us expect more severe dengue outbreak in the Americas in the coming years?

Christine Prat

Hi Harold, I was at the American Society of Virology conference last month, and Dr Eva Harris presented some results on that subject on a Nicaragua population if I recall correctly. You might want to check her publications or contact her directly. She mentioned this Review you might have seen already: https://www.ncbi.nlm.nih.gov/pubmed/28655548 (Andrade et al, Virus Research June 2017).

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