From a transplant perspective, nephrotoxicity can be an issue. Depends as to which type of formulation you are using and whether you are monitoring drug levels-

http://reference.medscape.com/drug/neoral-sandimmune-cyclosporine-343196

Long term side effects include an increased risk of malignancy as well as the risk of infection.

Psoriasis !

Patients treated with cyclosporine isolated or in association to other drugs ?

Doses ? How long ? and monitorization ?!

Dosage and Administration of cyclosporin for Psoriasis

Gengraf , Neoral PO Start with 1.25 mg/kg twice daily for at least 4 wk, barring adverse reactions. Increase dosage at 2-wk intervals if significant clinical improvement has not occurred. Based on patient response, increase the dose by approximately 0.5 mg/kg/day at 2-wk intervals (max, 4 mg/kg/day). Discontinue if satisfactory response cannot be achieved by wk 6 of therapy at 4 mg/kg/day or the patient's max tolerated dose.For its role in renal toxicity plz see the following paper.

Have a nice Day

http://www.drugs.com/ppa/cyclosporine-cyclosporin-a.html

Article Cyclosporine nephrotoxicity

Chapter Clinical Aspects of Cyclosporine Nephrotoxicity

Dear Amerigo,

I had some patients that needed a long term CyA treatment, because they do respond to a short term one but immediately they relapsed. Dose was usually 5 mg/kg QD. Of course it is needed to control blood pressure and lab analysis, particularly creatinine clearance, cholesterol, triglycerides  etc . If one year treatment was not enough to control and avoid immediate recurrences, I asked opinion of nephrologist before to continue and evaluated the risk/benefice of another therapy. I had no problems in my private patients, not so many, I treated as I mention. When they had a pathological background I preferred to refer them to our department where we treated them with help of other specialists. There is an updated short version guidelines of systemic treatment of psoriasis in the JEADV 2015; 29, 2277-94.

Warmest regards from your old friend Jose.

Thank you Professor Mascaro

in times where people use byologic therapy without trying the "old" drugs is very important your testimony. 

Have you any time try the association of CyA with MTX both in half doses ?

This is really a very good option before any heavy treatment.

Best regards good friend and teacher.

américo