The word ‘atopy’ was introduced by Coca in 1923 as a convenient collective term for a group of diseases, chief among which are asthma and hay fever, which occur spontaneously in individuals who have a family history of susceptibility.
In one of our researches regards H. pylori and skin manifestations (EdHpSm) it was found that prevalence of EdHpSm Associated disease is Hay fever represents 29.3% and bronchial asthma 12.1% respectively as highest associations.
Bashir A. H. H.1,2*, Yousif S. M.2 and Mahmoud M. O. A.2. Clinicoepidemiological study in Sudanese patients:Prevalence and effect of eradicative triple therapy on extra digestive Helicobacter pylori skin manifestations,
EdHpSm. Clinical Reviews and Opinions Vol. 3(2), pp. 14-19, February 2011.
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ISSN 2141-2553 ©2011 Academic Journals
it is rather a collective term for a group of diseases like asthma, hay fever, allergic rhinitis ad eczema: they all share (by atopy ) genetic predisposition for an abnormal reaction to the environment ( bronchial, dermatologic, or nasal). they have different phenotypic presentation although they share common locus on the chromosomes and different ones too that are behind the different phenotypes.
Dr Soferman as an association or a collective. Do have any explanation for the relation. Thanks.
Both bronchial asthma and Hay fever are atopic diseases generally. However, there are many cases of chronic asthma where the patients are not atopic and display a neutrophilic phenotype rather than the eosinophilic inflammation typically seen in atopic patients. There are therefore atopic or allergic and non-allergic asthmatics while allergic rhinitis is a classic type I hypersensitivity reaction.
The term "atopy" means out of place. Many physicians and scientists use the term "atopy" for any IgE-mediated reaction (even those that are appropriate and proportional to the antigen), but many pediatricians reserve the word "atopy" for a genetically mediated predisposition to an excessive IgE reaction. A person with atopy typically presents with one or more of the following: eczema (atopic dermatitis), allergic rhinitis (hay fever), or allergic asthma. Some patients with atopy display what is referred to as the “allergic triad” of symptoms.
allergic rhino-sino-tonsilo-adeno-bronchitis is the correct name of these two condition. in fact you can not manage asthma without considering underlying allergic inflammation of the upper airways and vice verca. Hence the unified airway theory or principle is the correct terminology.
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