Vitamin D is prescribed to all those with low levels. However is vitamin D3 be expected to positively affect the metabolic parameters? Meta-analysis say they have no effect. Are we looking at the right effect in abnormal value over a short time span of any study and expect a change?
I disagree with this statement as we are conducting an experimental study on the effects of VitD in type II DM and the results are promising. We are also planning to extend the study and include type 1 and gestational DM. The use of VitD in patients with polycystic ovary has also been shown beneficial in terms of insulin resistance.
many studies have suggested that supplementation of vitamin D3 provides a potential benefit in several disorders, including DM and immune-related diseases.
Low vitamin D may be related with some metabolic changes. However, vitamin D supplementation does not provide any benefit unless circulating levels are < 12 ng/mL. There are many papers on the matter, including observational studies and systematic reviews.
Vit D3 influences positively bone metabolism and nerve tissue metabolism ..., and through Ca++ metabolism, plausibly, every other process in the body. Maybe in D3-sufficient population, D3 supplementation could give a window of no-change up-until a hyper-vitaminosis state will be reached, when supposedly negative effects are to be expected. For that, I imagine, a researcher would elect a tropical country for a population sample, if we can claim that a hyper-rvitaminosis state aim is an ethical aim in a study.
In our experience an intensive use of low weekly doses of 25(OH) D3 in dialyzed patients to reach at least 30 ng/ml shown a reduction in serum PTHi, a reduction in calcitriol and paracalcitol use, no significative changes in serum Ca and P.
NO! The abnormalities of glucidic and lipidic metabolisms improve after days of VD supplimentation !
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