Do y ou have any data on gene expression of ubiquitin ligases in depression?

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Liliana Georgia Ciobanu

We have generated the genome-wide gene expression data.

I didn't finalize the analyses yet, but I see some ubiquitin-related alterations.

Jerry Vriend

Thanks for your response. You probably have some very good data on clinically relevant genes associated with depression since you have the genome-wide expression data. It would take a little effort (a few days) to identify all the E3 ubiquitin ligases and the E2 ubiquitin conjugases in your data, but it might make an interesting story. I assume you haven't made public the expression data but I would like to see it when it is published or made available as a database. For a relatively painless method of identifying E2 and E3 ligases see my recent 2017 paper in PlosOne (PMID: 28212404).

Best wishes in the success of your project.

Here is the full-text of the article. More details on ubiquitin-related pathways in depression can be found in Supplementary material (Table S6).