Tumor heterogeneity and metastasis correlate with the clinical aggressiveness of cancer. What is the future direction in this field of science? Please share it?
Dear Abhishek
There are genes that enhances metastatic potential of malignant tumors. These genes are found frequently in different cancers. But I rather refere you for a better understanding to the following publications:
https://www.researchgate.net/profile/Rene_Bernards/publication/11196516_Metastasis_genes_A_progression_puzzle/links/0c9605358097028985000000.pdf
http://www.nature.com/nature/journal/v436/n7050/full/nature03799.html
http://www.nature.com/nature/journal/v459/n7249/abs/nature08021.html
http://www.nature.com/ng/journal/v33/n1/abs/ng1060.html
I hope these publications, specially the first one by Robert Weimberg will answer your question.
Regards
Article Metastasis genes: A progression puzzle
Have a careful reading of the attached articles.
Then, you will be able to respond by yourself to your own question.
Best regards
Robert
Two things to investigate: first, cancer stem cells. If the CSC hypothesis is correct, (and it appears to be so when functional definitions of CSCs are used), then metastasis of tumor cells other than CSCS cannot be productive of a new tumor site. It would also be necessary for the CSC that metastasized to have found a new niche site to establish itself and the new tumor site. Second, it is unlikely that metastasis genes are only in tumor cells or those that had or about to metastsize. They are likely to be in all cells, but are not expressed in most primary tumor cells.
ft umor
Yes Masoud!
The attached article fully and actually validate your response to Abhishek.
Best regards
Robert
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