Modelers can make any thing possible, so answer could be 'no'. But from real physics point of view answer could be 'yes'. I am eagre to know ways to tackle the situation if answer is 'yes'.

“some thing is better than nothing’ this statement could be more true in routine way or issues, but may be not equally factual in natural science like hydrology. I would like to put a hypothetical scenario - when for a given catchment (say 2000 ha) we have continuous river flow data at the interval of 6 hrs, but the available rainfall data is only at 24 hr time step i.e. daily value. River has continuous flows, giving hydrographs of broader bases say 15 to 20 days atleast. For generating runoff prediction models, this partially gauged catchment is as good as an ungauged catchment ( in want of accurate rain input data). How to deal such situation ? What are the innovative ways to move ahead for coming over to such deficit at one end and carving out some regional predictive models for totally ungauged locations on other hand, eliminating uncertainties of predictions/simulations in accordance to prevailing physics/phyisiographical configurations of catchments.        

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