Do solvated drug targets undergo a conformational change? If so, could this conformational change be accounted as a cause of drug resistance?

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What are the BS VI and Euro 6 emission norms for diesel engine in g/kwh not g/km?

I need BS VI and Euro 6 emission norms for diesel engine in g/kwh But it is available in g/km How to i get it in g/kwhr?

13 May 2024 4,680 2 View

What is the solution for vanadium enrichment in AOD convertor slag?

We are doing vanadium impurity removal in AOD process. We can achieve the vanadium oxidation in the liquid metal and mil scale is used a crust forming agent. However, we couldn't t able to remove...

07 March 2024 7,411 0 View

Is it any way separate vanadium from sulphuric acidic solution contains 10gpl V with 25 gpl of Al ?

We are leaching vanadium from iron slag using sulphuric acid at 0.5 pH. The leaching liquor contains 9-11 gpl of vanadium along with 20 to 25 gpl of aluminum leaching and 2 gpl iron. What is the...

15 February 2024 3,184 0 View

What is the impact of TiO2 present in the iron ore in DRI process?

we are facing pellet carking in the DRI pellet with >4% TiO2 in the raw material. \is there any solution to control the pellet cracking in the downstream process. |Thanks in advance

04 January 2024 5,360 8 View

How to interpret the results of my factor analysis or change them accordingly?

Hello, I have first cleaned the data by handling all missing values. 1. I have done factor analysis for four variables regarding environmental concern. 2. I used PCA and Varimax 3. I have got...

08 September 2023 9,467 3 View

How to calculate sample size for multi-arm (three arm) RCT?

21 April 2023 4,910 1 View

How to calculate the energy share in the hydrogen usage in the RCCI engine?

How to calculate the energy share in the hydrogen usage in the RCCI engine? How to calculate energy share?

10 March 2023 2,333 0 View

What is the different between HCCI, PCCI, RCCI and GDCI combustion?

What is the different between HCCI, PCCI, RCCI and GDCI combustion? in RCCI which type of LRF and HRF used?

24 February 2023 6,521 5 View

Gromacs isn't reading/accepting the index.ndx file?

Please see the snapshot below, while the index groups have been created and are non-empty groups, the gmx2020 installation isn't computing rg for the desired group.

23 January 2023 3,827 0 View

How to convert the IC engine exhaust gas emission measurement in ppm and % into g/kWh and g/Km?

How to convert the IC engine exhaust gas emission measurement in ppm (NOx, HC) and % (CO, smoke & CO2) into g/kWh and g/Km?

27 December 2022 4,074 2 View

Why my colony PCR results of my recombinant bacterial not showing any results?

I am performing ligation of the plasmid and a target gene. The steps I have taken are: 1. Double digestion of the plasmid and target gene 2. Ligation of the plasmid with the target gene 3....

05 August 2024 2,570 3 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Why my negative control siRNA is decreasing the target gene's expression?

Hi Everyone, I'm using an siRNA kit to knock down a target gene. The kit guarantees that the negative control doesn't target any sequence in mouse genome, and when I use BLAST I don't find any...

23 July 2024 2,673 6 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

19 July 2024 8,522 0 View

How to extract binding energy from pv.maegz file without using Schrodinger?

I have conducted virtual screening using Schrödinger on a database of 17,000 molecules. Unfortunately, I cannot use the system with the Schrödinger license at the moment. I am trying to find a way...

18 July 2024 2,881 4 View

Use of NC or NTC to descibe negative control?

Hello, I would like to ask which is the best terminology to use for describing a negative control in an experiment (drug testing in-vitro, viral infection): NC (negative control) or NTC? Thank you...

18 July 2024 4,183 2 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

15 July 2024 2,414 1 View

How to calculate percentage cumulative drug release?

How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...

15 July 2024 4,192 1 View

Abnormal data in in-vitro drug release study?

I'm doing in-vitro drug release study using dialysis bag method and collecting samples from the external medium at several time points, subjecting to UV-Vis spectrophotometry. But my absorbance...

14 July 2024 6,829 2 View