Probiotics are certainly helpful and we need them. When we take antibiotics we certainly lose some probiotics, which some of us experience. Has there been any studies done to determine if probiotics also develop resistance to antibiotics as do the pathogens?
This paper is useful
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714544/
Taken from the abstract
"With some exceptions, antibiotic resistance in these beneficial microbes does not constitute a safety concern in itself, when mutations or intrinsic resistance mechanisms are responsible for the resistance phenotype. In fact, some probiotic strains with intrinsic antibiotic resistance could be useful for restoring the gut microbiota after antibiotic treatment. However, specific antibiotic resistance determinants carried on mobile genetic elements, such as tetracycline resistance genes, are often detected in the typical probiotic genera, and constitute a reservoir of resistance for potential food or gut pathogens, thus representing a serious safety issue."
Hope helpful
You can read about the regulatory thinking/concerns here:-
http://www.efsa.europa.eu/en/efsajournal/doc/587.pdf
Resistance is likely to happen with long term use of antibiotics. It will be beneficial if this happens, because we still need those probiotic organisms to maintain gut microbiota. Also, the microbiota regenerated after this therapy will probably be genetically resistant to next antibiotic therapy.
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