I have a question. Do prior immunity to a virus-like particle vaccine platform affects its immunogenicity for the next vaccination? For example, if we vaccinate an individual using a chimeric VLP consist of an antigen of interest fused into influenza M1 protein as the core, will it have a lower immune response if the individual were vaccinated with other VLP-based vaccine containing the same M1 protein? Will it happen as with the viral vector vaccine?

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