Could anyone provide me with comprehensive reviews or articles demonstrating that certain marine organisms biosynthesize or accumulate (from external origin) prodrugs that are specifically detrimental to specific predators? In other words, these metabolites acting as prodrugs would be without any effects on non-predators, while active against predators, which “unfortunately” (for them) possess the biochemical machinery to transform the inactive pro-drug into an active compound detrimental for them.
Thank you for your help.
Robert
Dear Robert,
Attached is a recent review article which covers this topic.
Hoping this will be helpful,
Rafik
Thank you Rafik.
I had already this article but unfortunately it does not contain any responses to my question.
Best regards
Robert
Hi Robert,
I know of potent antimitotic drugs derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins. A bit of googling around should get you there....
Yours,
Andrei
Dear Robert, some marine invertebrates contain compounds possessing some functional groups very active that could be maskered in a form less toxic. One example is given by caulerpenyne/oxytoxin-1/oxytoxin-2 from the alga Caulerpa prolifera and a series of sacoglossan mollusks that feed on it. The mollusks are able to biotransform caulerpenyne (that possess two maskered aldehydes) into more toxic compounds (oxytoxin-1 and -2) that could be used as defensive weapons against their predators. But, to be honest, I don't know these compounds could be considered as pro-drugs. I'm sure that in literature there are other examples, for sure. I attach two papers on Caulerpa/sacoglossans.
Bye, Letizia
Thank you Andrei.
I submitted one week ago a review that I hope to be accepted in a "good" journal...
I dedicated a "nice" part of this review to dolastatins ... that definitively do not behave as "pro-drugs" ...
All the best,
Robert
Dear Joe,
French .. or ... English ... or Spanish ...
I have more than huge difficulties in responding you in English because my mother languages are / were 1) Hungarian , 2) Swahili, 3) French ... thus let's go on French ...
It was a joke ... (while I actually admitv that English and me are not the best friends!!!).
I know very well all the works published by Pharmamar ... but I actually emit serious doubts about the fact that "Pharmamar" will respond me ... But who knows ...
Cher Joe, c'est la vie et nous devons nous y plier car ...
But ...
Salut ...
Bobby
Dear Robert,
I have reread the review article that I attached to my first answer and found that halichondrin E7389 (halichondrin B) anti-cancer agent described in the review can be classified within the compounds you are looking for.
By the way the products of Pharmamar company mentioned by Joe are also described in the review article.
Best wishes,
Rafik
Thank you Rafik.
I think that there is a missunderstanding between us.
Would you be so kind in indicating me how halicondrin E7389 acts as an actual pro-drug and against which predator.
I need at least one good article about this process.
Thank you very much.
Dear Rafik,
E7389 is eribulin mesylate, a "human-build" analogue of halichondrin B.
E7389 does not fit with my query.
I am searching for natural compounds (not semi-synthetic or synthetic analogs) synthesized by certain organisms as prodrugs, which is turn become cytotoxic drugs in specific predator species.
Best regards
Robert
Best is to ask at U Paris, Villefranche sur mer branch where they work (or at least used to) on marine toxicology and planctonnic poisons. I used to research there during my thesis...
Yes Rafik, .... I know that Halichondrin B is a natural product, while E7389 is an analog ...
I am asking you to send me an article bringing solid scientific proofs about the fact that halichondrin B acts as a prodrug against certain predators.
I do not need the scientific literature about the anticancer effects of halichondrin B and its analogues: I already have these publications ...
Robert
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