Obviously a brain abscess is a very serious condition, but CT-guided biopsy of the brain is also very invasive. Must brain abscesses always be biopsied? If so, is it because the consequences of inappropriate antibiotics treatment are so grave?
As you stated above, brain abscess is a very serios clinical condition. Proper antibiotic treatment should be initiated as soon as possible in guidance of microbiological assay. Needle aspiration with CT guidance is a proper choice of diagnosis. Some patients should benefit from sole antibiotic treatment (Infect Dis Clin North Am. 2009 Sep;23(3):609-23), however, surgery is still essential in treatment of brain abscess. For more information please refer to: https://reference.medscape.com/article/212946-treatment