Alpha-glucosidase inhibitors are used in humans (miglitol, acarbose).
There seems to be some in Grifola frondosa too. (Matsuur H et al. Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa. Biosci Biotechnol Biochem. 2002 ; 66:1576-8).
A more recent publication on the (possible) effect of this mushroom on diabetes is: Lei H, Zhang M, Wang Q, Guo S, Han J, Sun H, Wu W.: MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81.