The lack of instrumentations and techniques.. would make it difficult for researchers from developing countries to carried out researches in the best way! What types of other problems may face researchers in such country?
There are limited resources to support research projects because sources of funding are so scarce.Time to devote to research is difficult to find because people who teach at the university level in developing countries are rarely full time professors and usually have several jobs.Universities in many developing countries lack the structure of ethical review committees. Even if a researcher wants to verify ethical treatment of human subjects there is no mechanism in place to do so.
As mentioned by Mr Tejus there are any number of reasons in developing countries acting as impediments for true research . One major problem I find is lack of enthusiasm or genuine interest in research from the top to the bottom . Many a times it works as an extension of the government bureaucracy which involves corruption and nepotism . It is also considered as a routine work !. So the by products of such culture are non allocation of sufficient funds in time, plagiarism, lack of responsibility etc which leads to substandard research!!