In 1987, a study showed that administration of armin, an irreversible inhibitor of acetylcholinesterase, by injection 24 hours before sepsis modelling invoked essential depression of a lethality of mice from experimental infectious process.[2] Later (in 1995) this data has been confirmed at cholinergic stimulation by other cholinomimetics.[3] Inhibitors of acetylcholinesterase can cause higher accessibility of acetylcholine and activation of cholinergic anti-inflammatory pathway as well.
Zabrodskiĭ, PF (1987). "Effect of armin on nonspecific resistance factors of the body and on the primary humoral immune response". Farmakologiia I Toksikologiia. 50 (1): 57–60. PMID 3549354.
^ Zabrodskiĭ, PF (1995). "Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation". Bulletin of Experimental Biology and Medicine. 120 (2): 809–811. doi:10.1007/BF02445960. S2CID 31513646.