I am trying to understand how depolarisation induced with KCl or glutamate/ NMDA or any such stimuli leads to the balance of actin polymerization: actin depolymerization in neurons. Is it possible that actin depolymerization precedes actin polymerization as an immediate step post depolarization. How does it fit the spine dynamics post depolarization. This relates to temporal dynamics of actin organization in the neurons post depolarization. I think if actin depolymerization precedes polymerization for few minutes (30-1 hr) post depolarization it will help the spines to be flexible and let the movement of receptors and function of other spine machinery possible. It might also help to let the new dendritic mRNA and newly synthesized proteins to enter the spines and take their appropriate functions. Does this concept sound logical? Or are there other possibilities?
Hi Apurva,
I think this paper will help your conceptual questions but this one is more focused and single molecular study but the references will be more helpful.
Neuron. 2015 Aug 19;87(4):813-26. doi: 10.1016/j.neuron.2015.07.023.
A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII.
Kim K1, Lakhanpal G2, Lu HE3, Khan M2, Suzuki A1, Kato-Hayashi M4, Narayanan R4, Luyben TT5, Matsuda T6, Nagai T6, Blanpied TA7, Hayashi Y8, Okamoto K9.
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