Is there a reason why the pioneering and potentially important findings of Dr. Gualano (Gualano B, Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Med Sci Sports Exerc. 2011May;43(5) showing! ~1% decrease of HBa1c in patients taking creatine supplements even in the presence of metformin !) were not tested anywhere in larger clinical trials?
A follow up on my question:
Löbner J, Degen J, Henle T. Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr). J Agric Food Chem. 2015 Mar 4;63(8):2249-56.
So why is nothing happening ?
Dear Benjamin,
I am not an expert in clinical population, but I saw your question and having bibliography on the suplementation topic... it seems wrong not to try to help you, for it, I send you a paper, I hope it serves you.
Gualano, B., Painneli, V. D. S., Roschel, H., Artioli, G. G., MANOEL NEVES, J. R., Pinto, A. L. D. S., ... & Ferreira, J. C. (2011). Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Medicine & Science in Sports & Exercise, 43(5), 770-778.
Best regards
People with diabetes and / or kidney disease should also avoid taking creatine. Research has shown that taking supplements can make certain cases worse. Also, taking a higher dose than recommended can cause kidney damage and increase the chances of developing kidney disease or damage.