Cre mice specific for T lymphocyte (beside CD4 and LCK-cre

Yair Botbol @Yair-Botbol

01 January 1970 1 6K Report

Dear colleagues,

Am looking for a Cre mouse, with specific expression of cre in T lymphocytes, apart from the CD4-cre and LCK-cre mice.

tks a lot

Michael Förster

Dear Yair Botbol

please check, if the hCD2-cre mouse serves your purpose. I have attached a publication for cre mediated deletion kinetics comparing hCD2-, Lck- and CD4-cre mice in the thymus. Please check:

Article Activation Kinetics and Off-Target Effects of Thymus-Initiat...

The mouse strain in question you will find here: https://www.jax.org/strain/027406

And our comparison of Lck-cre and CD4-cre mediated deletion in thymus and peripheral T cells, respectively, you will find here:

Article A role for the histone H2A deubiquitinase MYSM1 in maintenan...

A reviewer of my results suggested hCD2-cre mice to investigate T cell specific deletion at the earliest stages in thymic development, so I hope that helps.

All the best & kind regards,

Michael

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