Could you please introduce me paper(s) which describe peritoneal dialysis rats well?
" Physiol. Res. 60: 157-164, 2011
A New Non-Uremic Rat Model of Long-Term Peritoneal Dialysis
Y.-M. PENG et all. "
May be you can find some answers in this apper
Microcirculation. 2010 May;17(4):271-80. doi: 10.1111/j.1549-8719.2010.00024.x.
Peritoneal dialysis fluid bioincompatibility and new vessel formation promote leukocyte-endothelium interactions in a chronic rat model for peritoneal dialysis.
Schilte MN1, Fabbrini P, Wee PM, Keuning ED, Zareie M, Tangelder GJ, Van Lambalgen AA, Beelen RH, Van Den Born J.
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Abstract
Peritoneal dialysis (PD)-induced peritonitis leads to dysfunction of the peritoneal membrane. During peritonitis, neutrophils are recruited to the inflammation site by rolling along the endothelium, adhesion, and transmigration through vessel walls. In a rat PD-model, long-term effects of PD-fluids (PDF) on leukocyte-endothelium interactions and neutrophil migration were studied under baseline and inflammatory conditions. Rats received daily conventional-lactate-buffered PDF (Dianeal), bicarbonate/lactate-buffered PDF (Physioneal) or bicarbonate/lactate buffer (Buffer) during five weeks. Untreated rats served as control. Baseline leukocyte rolling and N-formylmethionyl-leucyl-phenylalanine (fMLP) induced levels of transmigration in the mesentery were evaluated and quantified by intra-vital videomicroscopy and immunohistochemistry. Baseline leukocyte rolling was unaffected by buffer treatment, approximately 2-fold increased after Physioneal and 4-7-fold after Dianeal treatment. After starting fMLP superfusion, transmigrated leukocytes appeared outside the venules firstly after Dianeal treatment (15 minutes), thereafter in Physioneal and Buffer groups (20-22 minutes), and finally in control rats (>25 minutes). Newly formed vessels and total number of transmigrated neutrophils were highest in Dianeal-treated animals, followed by Physioneal and Buffer, and lowest in control rats and correlated for all groups to baseline leukocyte rolling (r = 0.78, P < 0.003). This study indicates that the start of inflammatory neutrophil transmigration is related to PDF bio(in)compatibility, whereas over time neutrophil transmigration is determined by the degree of neo-angiogenesis
The peritoneal equilibration test (PET) is used to determine peritoneal transport in peritoneal dialysis patients.
References
1. Pannekeet M, Imholz A, Struijk D, Koomen G, Langedijk M, Schouten N, de Waart R, Hiralall J, Krediet R (1995). "The standard peritoneal permeability analysis: a tool for the assessment of peritoneal permeability characteristics in CAPD patients.". Kidney Int 48 (3): 866–75. doi:10.1038/ki.1995.363. PMID 7474677.
2. Twardowski ZJ1, Prowant BF, Moore HL, Lou LC, White E, Farris K (2003). Short peritoneal equilibration test: impact of preceding dwell time. Adv Perit Dial. 19:53-58.
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