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Dear Dr.

https://doi.org/10.1016/j.phrs.2020.104791

https://www.sciencedirect.com/science/article/pii/S1043661820310999/pdfft?md5=e02f5ab3f30cff0f891e391dc9b52cf9&pid=1-s2.0-S1043661820310999-main.pdf

IL-17A is a pro-inflammatory cytokine mainly produced by Th17 cells, but also by innate and other adaptive immune cell components such as natural killer T cells, macrophages, neutrophils, CD8+ T cells, γδ T cells and innate lymphoid cells [supplementary material.

Th17 responses in patients with SARS-CoV-2. They found that peripheral blood cells from patients with severe COVID-19 infection had strikingly high numbers of circulating Th17 cells which were associated with a “cytokine storm” including IL-1β, IL-2, IL-7, IL-10, IL-17, G-CSF, interferon γ-induced protein 10 (IP-10), MCP-1, macrophage inflammatory proteins (MIPs) and TNF-α. As a result of this hyper-inflammatory state, the authors suggested the use of Fedratinib, a Janus kinase 2 (JAK2) small molecule inhibitor which is involved in the suppression of signal transducer and activator of transcription 3 (STAT3), as a potential therapeutic agent for patients with elevated Th17 (but also Th1) type immune profiles

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May be

Hi Dr.

https://www.ncbi.nlm.nih.gov/pubmed/32302707

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https://www.google.com/url?sa=t&source=web&cd=1&ved=2ahUKEwjK1tjSp4HpAhUMDuwKHWJBBTMQFjAAegQIBxAC&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fm%2Fpubmed%2F32302707&usg=AOvVaw2azlUrJ6L__zmwRLqYy_eV

May be

PubMed journal article Could IL-17 represent a new therapeutic target for the treatment and/or management of COVID-19-related respiratory syndrome?

Maybe

IL-17A is a pro-inflammatory cytokine mainly produced by Th17 cells, but also by innate and other adaptive immune cell components such as natural killer T cells, macrophages, neutrophils, CD8+ T cells, γδ T cells and innate lymphoid cells [supplementary material.

Th17 responses in patients with SARS-CoV-2. They found that peripheral blood cells from patients with severe COVID-19 infection had strikingly high numbers of circulating Th17 cells which were associated with a “cytokine storm” including IL-1β, IL-2, IL-7, IL-10, IL-17, G-CSF, interferon γ-induced protein 10 (IP-10), MCP-1, macrophage inflammatory proteins (MIPs) and TNF-α. As a result of this hyper-inflammatory state, the authors suggested the use of Fedratinib, a Janus kinase 2 (JAK2) small molecule inhibitor which is involved in the suppression of signal transducer and activator of transcription 3 (STAT3), as a potential therapeutic agent for patients with elevated Th17 (but also Th1) type immune profiles

Agrer with dr. Basim Mohammed Hanon

Hi Dr.

https://www.google.com/url?sa=t&source=web&cd=4&ved=2ahUKEwjVleSMr4HpAhUD2qQKHdfPDNAQFjADegQIBBAB&url=https%3A%2F%2Fclinowl.com%2Fcould-il-17-represent-a-new-therapeutic-target-for-the-treatment-and-or-management-of-covid-19-related-respiratory-syndrome-this-paper-is-dedicated-to-sofia-maione-born-during-covid-19-outbreak%2F&usg=AOvVaw3zQyogbsxhgjnXGOZEK2zu

https://www.researchgate.net/deref/https%3A%2F%2Fdoi.org%2F10.1016%2Fj.phrs.2020.104791

May be

Hi

May be

Article Could IL-17 represent a new therapeutic target for the treat...

Could be

May be

May be

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123803/

https://www.ncbi.nlm.nih.gov/pubmed/32302707

May be.

They need to more research and experiments

May be

Can be used in the future.

Article TH17 responses in cytokine storm of COVID-19: An emerging ta...

Hello Dr.

may be

May be

Article Could IL-17 represent a new therapeutic target for the treat...

I don't think that.

Hi dear Dr. Ayser

Many studies showed the elevated level of IL-17 in Severe cases of COVID-19 whose addmitted to intensive care unit. If you proposed to use IL-17 blockers as a strategy for treatment of CIVID-19 this may let the patients vulnerable for other intracellular infection.

https://www.ncbi.nlm.nih.gov/pubmed/32302707

Dear Dr.

https://pubmed.ncbi.nlm.nih.gov/32302707/?X

Article Could IL-17 represent a new therapeutic target for the treat...

https://clinowl.com/could-il-17-represent-a-new-therapeutic-target-for-the-treatment-and-or-management-of-covid-19-related-respiratory-syndrome-this-paper-is-dedicated-to-sofia-maione-born-during-covid-19-outbreak/

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Yes the balance for IL17 consider important for treatment several infection

May be

may be

Hi, Dr.

Pls see the following link

https://www.researchgate.net/deref/https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32302707%2F%3FX

it can be useful

Article Could IL-17 represent a new therapeutic target for the treat...

Good question dear Ayser .. I will try to know the suitable answer ... thanks

good work.

Article Could IL-17 represent a new therapeutic target for the treat...

yes

May be

Hi Dr.

May be

may be

Hello Dr.

Yes , due its role in immunemodulation

Following

https://www.researchgate.net/deref/https%3A%2F%2Fdoi.org%2F10.1016%2Fj.phrs.2020.104791