I want to do a project on network modeling, interest especially lies in gene-gene network and miRNA-mRNA network. Could anyone recommend some literature to start with?
miRNA has two regulatory functions, one is degrade mRNAs, the other is suppress the translation of mRNA. In the first case we can find out the inverse correlation between miRNA and mRNAs. But in the second case, it might not be easy to find such relationship, for that the expression of mRNA might not change. Do you know any literature working on this kind of modeling?